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BACKGROUND: The COVID-19 pandemic has led to a significant increase in cases of bronchiolitis among children. As a result, there has been a corresponding increase in the number of publications on this topic. It is essential to examine the main areas of focus within the scientific literature to understand the current trends in research on pediatric bronchiolitis. This research aims to analyze the types of scientific advances related to pediatric bronchiolitis, the research trends being pursued, and the countries and research institutions leading these efforts. By understanding these aspects of bronchiolitis research, we can better understand the current state of knowledge and identify areas where further research is needed. METHODS: To conduct a bibliometric analysis of the scientific literature on pediatric bronchiolitis, all relevant publications were retrieved from the Scopus database. The Scopus API and the SW VosViewer software with optimized modularity functions were used. This analysis was intended to provide a comprehensive overview of the current state of research on this topic, including the types of scientific advances being developed, the research trends being pursued, and the countries and research institutions leading these efforts. RESULTS: A total of 3810 publications were reviewed. We observed an increasing number of publications, particularly in recent years. Of these, 73.7% were articles, 95% were written in English, and 29.4% were from the United States. The main keywords used in these publications included: human, bronchiolitis, child, preschool, preschool child, major clinical study, controlled study, pneumonia, asthma, adolescent, hospitalization, infant, and newborn. These keywords were grouped into six clusters: outpatient management, long-term consequences, etiology, intensive care management, diagnostic methods, and the main cluster, which focused on hospital treatment and clinical studies. CONCLUSIONS: The bibliometric analysis of bronchiolitis research in pediatrics reveals that there has been a significant increase in the number of publications on this topic, particularly in recent years. Most of these publications are articles written in English and published in the United States. The main keywords used in these studies relate to various aspects of bronchiolitis, including diagnosis, treatment, and long-term consequences. The results of this analysis suggest that bronchiolitis is a topic of significant interest and concern for researchers and practitioners in the field of pediatrics and that further research is needed to improve our understanding and management of this condition.
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Asthma , Bronchiolitis , COVID-19 , Adolescent , Infant , Infant, Newborn , Child , Child, Preschool , Humans , Pandemics , Bronchiolitis/epidemiology , Bronchiolitis/therapy , BibliometricsABSTRACT
Background: Our Metabolic Genetics clinic serves as contracted consultants for the follow-up of abnormal metabolic newborn screens for all infants born in Oregon. We are a large (100,000 sq mi2), rural state and to serve our population we previously depended on primary care providers to help coordinate initial disclosure and follow-up diagnostic test collection for infants with abnormal metabolic results prior to an available office visit. In March 2020 our institution moved into "modified operations" which altered our workflows in unprecedented ways including dramatically expanding our use of telemedicine (both virtual video visits and telephone visits). Method(s): In order to fulfill institution requirements as well as to provide uninterrupted expedient follow-up of potentially affected babies identified by screening we expanded our use of telemedicine in this population. In most cases, these visits were offered for parents either in their homes or coordinated with their pediatrician's office. Metabolic Genetics clinic office visits were reserved only for critical cases. By 2022, our institution had returned to "normal operations", however, we continued to offer parents the option of a telemedicine visit or office visit in most abnormal screen follow-up cases. Result(s): The majority of newborn screen visits to our Metabolic Genetics clinic in 2020 and 2021 were conducted virtually with 74% in 2021. Despite loosening of COVID-era restrictions, in the first 9 months of 2022 we maintained this majority with 64% of infants initially seen via telemedicine (61% via virtual visit and 3% via telephone visit). Conclusion(s): Using telemedicine for metabolic newborn screen follow-up has reduced some of the Metabolic Genetic clinic's previous barriers including space, provider availability and timeliness. It has also been well-received by families for reducing barriers and stress and early signs indicate they prefer this method of follow-up. We feel this is a sustainable model for metabolic newborn screening follow-up in our program.Copyright © 2023
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Objectives: To measure the prevalence of viral infections, length of stay (LOS), and outcome in children admitted to the pediatric intensive care unit (PICU) during the period preceding the COVID-19 pandemic in a MERS-CoV endemic country. Methods: A retrospective chart review of children 0–14 years old admitted to PICU with a viral infection. Results: Of 1736 patients, 164 patients (9.45%) had a positive viral infection. The annual prevalence trended downward over a three-year period, from 11.7% to 7.3%. The median PICU LOS was 11.6 days. Viral infections were responsible for 1904.4 (21.94%) PICU patient-days. Mechanical ventilation was used in 91.5% of patients, including noninvasive and invasive modes. Comorbidities were significantly associated with intubation (P-value = 0.025). Patients infected with multiple viruses had median pediatric index of mortality 2 (PIM 2) scores of 4, as compared to 1 for patients with single virus infections (p < 0.001), and a median PICU LOS of 12 days, compared to 4 in the single-virus group (p < 0.001). Overall, mortality associated with viral infections in PICU was 7 (4.3%). Patients with viral infections having multiple organ failure were significantly more likely to die in the PICU (p = 0.001). Conclusion: Viral infections are responsible for one-fifth of PICU patient-days, with a high demand for mechanical ventilation. Patients with multiple viral infections had longer LOS, and higher PIM 2 scores. The downward trend in the yearly rate of PICU admissions for viral infections between the end of the MERS-CoV outbreak and the start of the COVID-19 pandemic may suggest viral interference that warrants further investigations. © 2022 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases
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INTRODUCTION: The clinical presentation of pregnant women with COVID-19 varied according to the time of the pandemic.
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Intrauterine growth restriction (IUGR) is a potential complication associated with maternal SARS-CoV-2 infection. Danish guidelines recommend ultrasound follow-up from gestational age (GA) 24+0 in SARS-CoV-2-positive pregnant women who experience reduced fetal movements. This is a case report of severe IUGR (-51%) after maternal infection at GA 22+1 in a healthy unvaccinated 28-year-old woman. Positive PCR-tests for SARS-CoV-2 from placenta and child, along with massive placental inflammatory findings, suggested IUGR caused by maternal infection. This implies that follow-up from earlier GA may be warranted.
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INTRODUCTION: Pregnant women continue to be vulnerable to COVID-19, and their immunosuppressed state could put them at greater risk of developing more severe forms of the disease. In Colombia and Latin America, there are few studies on the immune response of the newborn against SARS-CoV-2. AIM: To determine the prevalence of SARS-CoV-2 infection in umbilical cord blood in two hospital centers in Córdoba and Sucre. METHODS: Between March and June 2021, a prospective descriptive cross-sectional study was carried out. Two hospitals from the departments of Córdoba and Sucre, located in the Northwest Caribbean area of Colombia, participated. Three hundred sixty umbilical cord blood samples were taken at the two hospitals. A commercial ELISA was performed to detect total IgG, IgM, and IgA antibodies against the N protein of SARS-CoV-2. The ethics committee approved the study of the participating institutions. RESULTS: Of 3.291 women who gave birth in the hospital centers included in the study, 360 (11%) participated. Complete clinical data were obtained for 223 women. The mean age of the women was 24 years (range, 15-42). 29.4% (106/360) of the umbilical cord samples had total antibodies against SARS-CoV-2. Pregnant women did not have blood samples taken. 58% of the women were asymptomatic. There was no association between umbilical cord samples, clinical, epidemiological characteristics, and serological response to antibodies to SARS-CoV-2 (p > 0.05). CONCLUSIONS: The prevalence of umbilical cord blood samples was 29.4% for total SARS-CoV-2 antibodies. The study provides essential aspects for the epidemiological approach to neonates infected with SARS-CoV-2.
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Polio is a serious infection that is rare in the UK due to the vaccination programme. It is only found in a few countries worldwide and the chances of getting it in the UK are extremely low, according to the NHS.
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The interest in wearable wireless monitoring systems has accelerated secondary to the ongoing COVID-19 pandemic. Moreover, the alarmingly high number of infections in the pediatric population underscores a gap in monitoring these vulnerable populations, particularly in the home setting. This systematic review aims to identify and assess currently available wearables used to monitor cardiopulmonary function in infants and neonates. The study, prospectively registered on PROSPERO (CRD42020200642), completed a search of PubMed 1946-, Embase 1947-, Cochrane Library, Scopus 1823-, and IEEE Explore 1872-in June 2020. A total of 2324 unique citations were identified, with 16 studies describing 17 unique devices meeting inclusion criteria. Types of devices included smart clothing, belts, and mechanical adhesives, each with unique battery designs, data collection, and transmission hardware. Only four of the 17 devices underwent rigorous comparative testing, and three demonstrated correlation with the standard of care monitoring systems. Low sensitivity and specificity were reported in two commercially available consumer devices compared to the standard of care monitoring systems. The risk of bias in the entire cohort was highly based on a modified ROBINS-I scale. Further development and rigorous wearable device testing are necessary for neonatal and infant deployment.
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OBJECTIVE: This study systematically analyzed coronavirus disease 2019 (COVID-19) and vaccination details during pregnancy by using the national health insurance claims data. METHODS: Population-based retrospective cohort data of 12,399,065 women aged 15-49 years were obtained from the Korea National Health Insurance Service claims database between 2019 and 2021. Univariate analysis was performed to compare the obstetric outcomes of pregnant women (ICD-10 O00-O94) and their newborns (ICD-10 P00-P96) with and without COVID-19. Univariate analysis was also performed to compare the age and obstetric outcomes of pregnant women receiving different types of vaccines. RESULTS: The percentage of pregnant women with COVID-19 during pregnancy was 0.11%. Some obstetric outcomes of pregnant women with COVID-19, including the rates of preterm birth or cesarean delivery, were significantly better than those of pregnant women without COVID-19. The rate of miscarriage was higher in pregnant women with COVID-19 than without COVID-19. However, the outcomes of newborns of women with and without COVID-19 were not significantly different. Regarding vaccination type, obstetric outcomes of pregnant women appeared to be worse with the viral vector vaccine than with the mRNA vaccine. CONCLUSION: To the best of our knowledge, this is the first study to systematically analyze COVID-19 and vaccination details during pregnancy using the national health insurance claims data in Korea. The obstetric outcomes in pregnant women with and without COVID-19 and their newborns were similar.
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Background The increasing trend in COVID-19-associated multisystem inflammatory syndrome in children MIS-C has been reported as severe acute respiratory syndrome coronavirus 2 continues to spread worldwide. Impact of covid 19 on newborns remains uncertain, while low, but the risk of neonatal infection does exist. A study from China reported 3% of neonates had evidence of SARS-CoV-2 infection. Postnatal infection is considered through horizontal transmission, as SARS-CoV-2 testing on placenta, umbilical cord, amniotic fluid, vaginal secretions, and breast milk samples has been negative. Diagnosis of MIS-C is based on 6 criteria: pediatric age, persistence fever, raised inflammatory markers, signs of organ dysfunction, lack of an alternative diagnosis, and temporal relation to COVID-19 infection or exposure Method A CASE REPORT 24 days old neonate presented with fever, Reluctance to feed and Respiratory distress for 1 day. He was born to a mother G2P1 + 0 with no Co-morbid at 38 weeks gestation with APGAR scores of 8 at 1 minute and 9 at 5 minutes. Clinically he was febrile with heart rate of 270 beats per minute and respiratory rate of 70 breaths per minute. First and 2nd heart sounds were audible along with gallop rhythm. ECG showed rate of 270 & absent p wave suggestive of supraventricular tachycardia. INVESTIGATIONS His pro BNP 152772 pg/ml and trop I were significantly raised. Echocardiography was consistent with severe biventricular dysfunction and ejection fraction of 20 %. COVID antibodies were sent which were reactive. His inflammatory markers ferritin, LDH and D Dimer were strikingly raised. Two blood cultures and bio fire were negative, fulfilling the MIS-C criteria Adenosine was given twice with no improvement, IV amiodarone was added, which reverted SVT. IVIG was given. Results Improved echocardiographic led to extubation on day seven AND DISCHARGED Conclusion MIS-C in a neonate highlights the importance of considering the increasing spectrum of clinical manifestations, associated with SARS-CoV-2 infection. Further research is needed to make neonatal MISC guidelines
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The article offers information about the Covid-19 prevalence and outcomes in postpartum women and newborns in a community hospital system. It mentions that pregnant women are at a significantly increased risk for severe illness, pregnancy complications, and preterm delivery if they are infected with Covid-19.
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With the spread of coronavirus disease 2019 (COVID-19) in Korea, the number of pregnant women infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly increasing. A shortage of negative-pressure isolation rooms for newborns makes hospital assignment more difficult for late-pregnant women with COVID-19. Among 34 infants born to SARS-CoV-2-positive mothers, 5 (14.7%) presented with respiratory distress and 1 (2.9%) presented with feeding intolerance that required specialized care. Aerosol-generating procedures were performed in one infant. Overall outcomes of 34 infants were favorable, and no infant tested positive for SARS-CoV-2. Most infants born to SARS-CoV-2-positive mothers did not need to be quarantined in a negative-pressure isolation room, and 17 (50%) mother-infant dyads were eligible for rooming-in. If negative-pressure isolation rooms are selectively used for newborns requiring aerosol-generating procedures or newborns in respiratory distress, resource availability for lower-risk cases may improve.
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COVID-19 , Pregnancy Complications, Infectious , Respiratory Distress Syndrome , Female , Humans , Infant, Newborn , Infectious Disease Transmission, Vertical/prevention & control , Mothers , Pregnancy , SARS-CoV-2ABSTRACT
OBJECTIVE: To evaluate and report the clinical characteristics and outcomes of SARS-CoV-2 infection in pregnant women and newborns in Latin America. METHODS: Descriptive study based on the prospective report of the units of the Ibero-American Society of Neonatology Network. RESULTS: Of 86 pregnant women with COVID-19 confirmed by RT-PCR in seven countries (6 from Latin America, and Equatorial Guinea) 68% (59) were asymptomatic. Of 32% of symptomatic women, 89% (24) had mild symptoms and 3.5% (3) had severe respiratory symptoms. No women died. The cesarean section rate was 38%; gestational age was < 37 weeks in 6% of cases. RT-PCR was performed on all newborns between 16 and 36 hours of age; 6 (7%) were positive. All of them presented mild and transient respiratory distress; none died. Two newborns with negative RT-PCR died from other causes. Breastfeeding was authorized in only 24% of mothers; in 13% milk was expressed and 63% of newborns were fed with formula. In 76% of cases the motherchild pair was separated, and in 95% of cases the mother could not be accompanied at delivery or during the postpartum period. CONCLUSIONS: The lack of maternal accompaniment, the low rate of breastfeeding and the frequent separation of the mother-child dyad are of concern. The health care team must reflect on the need to defend humanized and family-centered care during this pandemic.
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The International Liaison Committee on Resuscitation initiated a continuous review of new, peer-reviewed published cardiopulmonary resuscitation science. This is the fifth annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations; a more comprehensive review was done in 2020. This latest summary addresses the most recently published resuscitation evidence reviewed by International Liaison Committee on Resuscitation task force science experts. Topics covered by systematic reviews in this summary include resuscitation topics of video-based dispatch systems; head-up cardiopulmonary resuscitation; early coronary angiography after return of spontaneous circulation; cardiopulmonary resuscitation in the prone patient; cord management at birth for preterm and term infants; devices for administering positive-pressure ventilation at birth; family presence during neonatal resuscitation; self-directed, digitally based basic life support education and training in adults and children; coronavirus disease 2019 infection risk to rescuers from patients in cardiac arrest; and first aid topics, including cooling with water for thermal burns, oral rehydration for exertional dehydration, pediatric tourniquet use, and methods of tick removal. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the quality of the evidence, according to the Grading of Recommendations Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations or good practice statements. Insights into the deliberations of the task forces are provided in Justification and Evidence-to-Decision Framework Highlights sections. In addition, the task forces listed priority knowledge gaps for further research.
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COVID-19 , Cardiopulmonary Resuscitation , Emergency Medical Services , SARS-CoV-2 , COVID-19/epidemiology , COVID-19/therapy , Humans , Infant , Infant, Newborn , Practice Guidelines as TopicABSTRACT
INTRODUCTION: Even though the risk of COVID-19 in pregnancy may be increased, large-scale studies are needed to better understand the impact of the infection in this population. The aim of this study is to describe obstetric complications and the rate of vertical transmission in pregnant women with SARS-CoV-2 infection. MATERIAL AND METHODS: Detected cases of SARS-CoV-2 infection in pregnancy were registered in Portuguese hospitals by obstetricians. Epidemiological, pregnancy and childbirth data were collected. RESULTS: There were 630 positive cases in 23 Portuguese maternity hospitals, most at term (87.9%) and asymptomatic (62.9%). The most frequent maternal comorbidity was obesity. The rates of preterm birth and small-to-gestational-age were 12.1% and 9.9%, respectively. In the third trimester, 2.9% of pregnant women required respiratory support. There were eight cases (1.5%) of fetal death, including two cases of vertical transmission. There were five cases of postpartum respiratory degradation, but no maternal deaths were recorded. The caesarean section rate was higher in the first than in the second wave (68.5% vs 31.5%). RT-PCR SARS-CoV-2 positivity among newborns was 1.3%. CONCLUSION: SARS-Cov-2 infection in pregnancy may carry increased risks for both pregnant women and the fetuses. Individualized surveillance and the prophylaxis of this population with vaccination. is recommended in these cases.
Introdução: Apesar do risco da COVID-19 na gravidez poder ser acrescido, são necessários estudos em larga escala para o melhor conhecimento do impacto desta infeção nesta população. O objetivo deste estudo é descrever as complicações obstétricas e a taxa de transmissão vertical em grávidas com infeção a SARS-CoV-2. Material e Métodos: Os casos conhecidos de infeção por SARS-CoV-2 na gravidez foram registados nos hospitais portugueses por obstetras. Foram recolhidos dados epidemiológicos, da gravidez e do parto. Resultados: Registaram-se 630 casos positivos em 23 maternidades portuguesas, a maioria no termo (87,9%) e assintomática (62,9%). A comorbilidade materna mais frequente foi a obesidade. A taxa de parto pré-termo e de leves para a idade gestacional foi de 12,1% e 9,9%, respectivamente. No terceiro trimestre, 2,9% das grávidas necessitaram de suporte respiratório. Verificou-se uma taxa de 1,5% de morte fetal, incluindo dois casos de transmissão vertical. Houve cinco casos de degradação respiratória no pós-parto, mas sem mortes maternas registadas. A taxa de cesarianas foi mais elevada na primeira do que na segunda vaga (68,5% vs 31,5%). A positividade do RT-PCR SARS-CoV-2 entre os recém-nascidos foi de 1,3%. Conclusão: A infeção pelo SARS-Cov-2 na gravidez pode acarretar riscos aumentados para as grávidas e fetos. Recomenda-se uma vigilância individualizada nestes casos e a profilaxia desta população com a vacinação.
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COVID-19 , Pregnancy Complications, Infectious , Premature Birth , Infant, Newborn , Female , Pregnancy , Humans , COVID-19/epidemiology , SARS-CoV-2 , Cesarean Section , Pregnancy Complications, Infectious/diagnosis , Pregnancy Complications, Infectious/epidemiology , Premature Birth/epidemiology , Pregnancy Outcome/epidemiologyABSTRACT
Introduction: Since the emergence of coronavirus disease 2019, known as COVID-19, there are limited data describing the risks and specific effects of severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, in pregnant women and their neonates. To date, there is scarce evidence of in utero transmission, and the risk of perinatal transmission and consequent neonate risk of developing COVID-19 during the perinatal period are also unknown. Methods: Since April 2020, universal screening of all pregnant women presenting in labor has been implemented in our hospital. To those who are positive for SARS-CoV-2, the possibility to room-in with the neonate is given. Neonates are tested for SARS-CoV-2 within the first 24 hours and again at 48 hours of life. We made a prospective cohort analysis of all neonates born of mothers positive for SARS-CoV-2 in our hospital from April to November 2020. Demographics, neonatal and maternal symptoms at the delivery, during hospitalization and once discharged, perinatal routine care and SARS-CoV-2 reverse transcription polymerase chain reaction results were studied. Results: We analyzed 23 mothers positive for SARS-CoV-2. Only eight declared having symptoms, mainly headaches, anosmia, and ageusia/dysgeusia. The 23 neonates were negative for SARS-CoV-2 in both reverse transcription polymerase chain reaction tests performed. All of the neonates were born and remained asymptomatic during the 14 days of surveillance time and all of them were breastfed. Discussion: According to our results, rooming-in was safe for newborns of SARS-CoV-2 positive mothers since there was no evidence of perinatal infection. This practice is a well-known way to promote early breastfeeding and encourage maternal-infant bonding. © Author(s) (or their employer(s)) and Portuguese Journal of Pediatrics 2021.
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COVID-19 is an infectious disease caused by the coronavirus called SARS-CoV-2, which was unknown until in December 2019, when the outbreak of viral pneumonia in Wuhan, China, was reported. Since different age groups are susceptible to this infection, including newborns, the objective of this article is to review scientific literature published in English language and available in PubMed database until April 21, 2020, related to epidemiological and clinical aspects in newborns with suspected or confirmed SARS-CoV-2 infection, as well as the recommendations for their management. In general, symptoms in newborns are milder (may even be asymptomatic) and compared to adults, their prognosis is more favorable. However special precautions are required to reduce the potential mother-to-child transmission, and to reduce the possibility of complications in symptomatic neonates.
La COVID-19 es una enfermedad infecciosa causada por el coronavirus SARS-CoV-2, desconocido hasta diciembre de 2019, cuando se reportó el brote de neumonías virales en Wuhan, China. Dado que diferentes grupos de edad son susceptibles a la infección, incluyendo los recién nacidos, el objetivo de este artículo es revisar la literatura científica disponible en la base de datos PubMed en idioma inglés hasta el 21 de abril de 2020, sobre los aspectos epidemiológicos y clínicos en recién nacidos con sospecha o confirmación de infección por SARS-CoV-2, así como las recomendaciones para su manejo. En general, los síntomas en los recién nacidos son más leves (incluso pueden ser asintomáticos) y, en comparación con los adultos, el pronóstico más favorable. Sin embargo, se requieren precauciones especiales para reducir el potencial de transmisión madre-hijo y reducir la posibilidad de complicaciones en los neonatos sintomáticos.
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INTRODUCTION: Guidance for pregnant women has been particularly problematic since the beginning of the COVID-19 pandemic. The aim of this study was to describe the characteristics and outcomes of pregnant women with SARS-CoV-2 infection and their newborns. MATERIAL AND METHODS: Case review of clinical records of pregnant women with SARS-CoV-2 infection admitted for delivery and their newborns from April to December 2020 at a hospital in the Lisbon metropolitan area. RESULTS: From 1755 births, 81 (4.6%) were from SARS-CoV-2 positive mothers. Most (83.9%) were term newborns. Almost 16% were preterm, while there was an overall prematurity rate of 9.9%. Most women (88.6%) were asymptomatic. Rooming-in occurred in 80.8% cases and 19.2% newborns were admitted to the Neonatal Intensive Care Unit. From the total, 56.7% newborns were breastfed from birth and 43% had mixed feeding. None of the newborns had symptoms related to COVID-19 infection, and all had negative rt-PCR for SARS-CoV-2 at birth and at 48 hours of life. The majority (85.2%) was discharged home with their mothers. DISCUSSION: Pregnant women with COVID-19 have shown immune characteristics resembling healthy pregnancies, and it is not yet clear if SARS-CoV-2 can be vertically transmitted. Recent updates on neonatal guidance now recommend rooming-in and support the relative safety of breastfeeding. CONCLUSION: This study supports other published articles regarding maternal and neonatal outcomes of SARS-CoV-2 infected pregnant women, including the absence of short-term adverse outcomes with rooming-in and breastfeeding.
Introdução: Desde o início da pandemia COVID-19, tem sido particularmente dificil obter orientações relativas a mulheres grávidas. Este estudo teve como objetivo descrever as características e resultados clínicos das grávidas com SARS-CoV-2 e dos seus recém--nascidos. Material e Métodos: Revisão de processos clínicos de grávidas com infecção por SARS-CoV-2 admitidas para o parto, e dos seus recém-nascidos, no período de abril a dezembro de 2020 num hospital da área metropolitana de Lisboa. Resultados: De um total de 1755 nascimentos, 81 (4,6%) foram de mães positivas para SARS-CoV-2. A maioria eram recém-nascidos de termo; 16% eram prematuros, sendo a taxa geral de prematuridade 9,9%. A maioria das grávidas (88,6%) foi assintomática. O alojamento conjunto ocorreu em 80,8% dos casos e 19,2% dos recém-nascidos foram admitidos na Unidade de Cuidados Intensivos Neonatais. A maioria dos recém-nascidos (56,7%) fez leite materno desde o nascimento e 43% fez aleitamento misto. Nenhum recém--nascido apresentou sintomas relacionados com a infeção por COVID-19 e todos foram negativos por rt-PCR para SARS-CoV-2 ao nascimento e às 48 horas. Do total, 85,2% dos recém-nascidos tiveram alta para o domicílio com a mãe. Discussão: As grávidas com COVID-19 apresentam características imunológicas semelhantes a grávidas saudáveis e ainda não é clara a transmissão vertical do SARS-CoV-2. Atualizações recentes sobre as orientações neonatais recomendam o alojamento conjunto e apoiam a segurança da amamentação. Conclusão: Este estudo corrobora resultados maternos e neonatais anteriores incluindo a ausência de resultados adversos a curto prazo com alojamento conjunto e amamentação.
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COVID-19 , Pregnancy Complications, Infectious , Female , Hospitals , Humans , Infant, Newborn , Infectious Disease Transmission, Vertical , Mothers , Pandemics , Portugal/epidemiology , Pregnancy , Pregnancy Complications, Infectious/epidemiology , Pregnancy Outcome , SARS-CoV-2ABSTRACT
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the first pandemic of the 21st century. SARS-CoV-2 infection is mainly transmitted via droplets. Although some cases of perinatal transmission have been reported, it is unclear whether these infections occurred via transplacental or transcervical routes or via environmental exposure. Herein, we present the case of a newborn who died with neonatal acute respiratory distress syndrome exhibiting severe pulmonary involvement. The baby was born to a COVID-19 PCR (+) mother by C-section and was found to be COVID-19 PCR (+) from a nasopharyngeal swab sample tested within 24 hours of birth due to the suspected transplacental transmission of SARS-CoV-2 from the mother to the fetus.
La enfermedad por coronavirus de 2019 (COVID-19), causada por el coronavirus 2 del síndrome respiratorio agudo grave (SARS-CoV-2), se convirtió en la primera pandemia del siglo XXI. La infección por SARS-CoV-2 se transmite principalmente a través de las gotículas. Si bien se han informado algunos casos de transmisión perinatal, no es claro si estas infecciones fueron resultado de la vía de contagio transplacentario o transcervical o de la exposición ambiental. En este artículo, presentamos el caso de un recién nacido que falleció por síndrome de dificultad respiratoria aguda neonatal con compromiso pulmonar grave. El bebé nació por cesárea de una madre con una PCR positiva para COVID-19 y se detectó que tenía una PCR positiva para COVID-19 mediante un hisopado nasofaríngeo en el transcurso de las 24 horas posteriores al parto debido a una sospecha de transmisión transplacentaria del SARS-CoV-2 de la madre al feto.